CGMD

Gene Descriptions


CGMD01-Acute Lymphoblastic Leukemia

Precursor B lymphoblastic leukemia Genes

BCR-ABL (translocation) HSA:613 25
MLL-AF4(translocation) HSA:4297 4299
E2A-PBX1(translocation) HSA:6929 5087
c-MYC(translocation) HSA:4609
TEL-AML1 (translocation) HSA:2120 861

 

Precursor T lymphoblastic leukemia Genes

NOTCH1 (mutation) HSA:4851
TAL1 (overexpression) HSA:6886
LYL1(expression) HSA:4066
MLL-ENL(translocation) HSA:4297 4298
HOX11 (translocation) HSA:3195
MYC (translocation) HSA:4609
LMO2 (translocation) HSA:4005
HOX11L2 (translocation) HSA:30012

 

Precursor B Lymphoblastic Leukemia Markers
BCR-ABL (translocation) HSA:613 25
MLL (rearrangement) 4297
E2A-PBX1 (translocation) HSA:6929 5087
c-MYC (translocation) HSA:4609
TEL-AML1 (translocation) HSA:2120 861
CD79a HSA:973
CD22 HSA:933
CD19 HSA:930
CD10 HSA:4311
CD20 HSA:931
TdT HSA:1791
CD24 HSA:100133941
WT1 HSA:7490

 

Precursor T Lymphoblastic Leukemia Markers
HOX11 (translocation) HSA:3195
CD3 HSA:915 916 917
TZR-alpha-beta (TCR)
TZR-gamma-delta (TCR)
CD2 HSA:914
CD5 HSA:921
CD8 HSA:925 926
CD10 HSA:4311
TdT HSA:1791
CD7 HSA:924
CD1a HSA:909
WT1 HSA:7490
CGMD02 -Acute Myeloid Leukemia

Genes

FLT3 (mutation) HSA:2322
c-KIT (mutation) HSA:3815
N-ras (mutation) HSA:4893
K-ras (mutation) HSA:3845
PML-RARalpha (translocation) HSA:5371 5914
AML1-ETO (translocation) HSA:861 862
PLZF-RARalpha (translocation) HSA:7704 5914
AML1 (mutation) HSA:861
C/EBPalpha (mutation) HSA:1050
PU.1 (mutation) HSA:6688

 

Markers

AML1-ETO (translocation) HSA:861 862
CBFbeta-MYH11 (inversion) HSA:865 4629
PML-RARalpha (translocation) HSA:5371 5914
CD13 HSA:290
CD33 HSA:945
CD14 HSA:929
CD64 HSA:2209
WT1 HSA:7490

 

CGMD03- Adrenocortical Carcinoma

Genes

ACTH-R (deletion) HSA:4158
GNAI2 (mutation) HSA:2771
N-ras (mutation) HSA:4893
IGF II (overexpression) HSA:3481
p53 (LOH, mutation) HSA:7157
p16/INK4A (LOH, low expression) HSA:1028
MEN1 (LOH, mutation) HSA:4221

 

 

 

Markers

Ki-67 HSA:4288
p21 HSA:1026
p27 HSA:1027

 

CGMD04-Anal Cancer

Genes

p53 (mutation) HSA:7157
DCC (mutation) HSA:1630
APC (mutation) HSA:324

 

Markers

p63 HSA:8626
SCC HSA:6317
TPA HSA:3856 3875 3880

 

CGMD05-Bile Duct Cancer

Genes

CA19-9
CEA HSA:1048

 

 

 

Markers

 

K-ras (mutation) HSA:3845
p53 (mutation) HSA:7157
c-Met (overexpression) HSA:4233
ERBB2 (overexpression, amplification) HSA:2064
COX2 (overexpression) HSA:5743

 

CGMD06-Bladder Cancer

Genes


H-ras (activating mutation)

HSA:3265

FGFR3 (activating mutation)

HSA:2261

HSA:1029

p53 (inactivating mutation or deletion)

HSA:7157

RB1 (deletion or hyperphosphorylation)

HSA:5925

EGFR (overexpression)

HSA:1956

ERBB2 (overexpression)

HSA:2064

RASSF1 (hypermethylation)

HSA:11186

DAPK1 (hypermethylation)

HSA:1612

 

Markers

BTA (Complement factor H-related protein)

HSA:3078

3080

10878

10877 81494

BTA (Complement factor H)

HSA:3075

NMP22

HSA:4926

Survivin

HSA:332

CY20

HSA:54474

Cytokeratin 8

HSA:3856

Cytokeratin 18

HSA:3875

Cytokeratin 19

HSA:3880

Hyaluronic acid

GL:G10505

HAase (hyaluronidase)

HSA:10724

Telomerase

HSA:7015

CEA

HSA:1048

Hemoglobin

HSA:3039

3040

3043

 

CGMD07-Brain Tumor

Genes

Glioma

EGFR (amplification, overexpression) HSA:1956
MDM2 (amplification, overexpression) HSA:4193
PTEN (mutation) HSA:5728
PDGF-A (overexpression) HSA:5154
PDGF-B (overexpression) HSA:5155
PDGFR-alpha (overexpression, amplification) HSA:5156
PDGFR-beta (overexpression, amplification) HSA:5159
CDK4 (amplification) HSA:1019
p53 (mutation) HSA:7157
RB1 (loss) HSA:5925

 

Neuroblastoma

MYCN (normal/amplified) HSA:4613
TrkA (high/low expression HSA:4914
TrkB (low/high expression) HSA:4915
TrkC (high/low expression) HSA:4916

 

Markers

Glioma

 

Neuroblastoma

MYCN HSA:4613
DNA index/ploidy/diploidy/triploidy
VMA (Vanillylmandelic acid) CPD:C05584
HVA (Homovanillic acid) CPD:C05582
CD44 HSA:960
TrkA HSA:4914
NSE HSA:2026
LDH HSA:3939 3945 3948 197257
Ferritin HSA:2495 2512
Multidrug resistance/associated protein
 
CGMD08-Breast Cancer

Genes

BRCA1 (germline mutation, hypermethylation) HSA:672
BRCA2 (germline mutation) HSA:675
p53 (mutation) HSA:7157
RB1 (underexpression) HSA:5925
PTEN (germline mutation) HSA:5728
c-MYC (overexpression) HSA:4609
ERBB2 (overexpression) HSA:2064
CDH1 (mutation) HSA:999
CCND1 (overexpression) HSA:595

 

Markers

CEA HSA:1048
MUC1(CA15.3) HSA:4582
MUC1(CA27.29) HSA:4582
Cytokeratin 8 HSA:3856
Cytokeratin 18 HSA:3875
Cytokeratin 19 HSA:3880
ERBB2 HSA:2064

 

CGMD09 - Cervical Cancer

Genes

K-ras (mutation) HSA:3845
H-ras (mutation) HSA:3265
EGFR (amplification) HSA:1956
ERBB2 (amplification) HSA:2064
p21 (overexpression) HSA:1026
CDK4 (overexpression HSA:1019
Bcl-2 (overexpression) HSA:596

 

Markers

HPV (Human papillomavirus) DNA (L1) VG:NC_001526_8
SCC antigen HSA:6317
CYFRA HSA:3880

 

CGMD10- Chronic Lymphocytic Leukemia (CLL)

Genes

Bcl-2 (overexpression) HSA:596
p53 (mutation) HSA:7157
ATM (germline and somatic mutation) HSA:472
Fas (absent) HSA:355

 

Markers

IgVH (mutational status)
CD38 HSA:952
ZAP-70 HSA:7535
Thymidine-kinase HSA:7083
CD23 HSA:2208
Beta-2 microglobulin HSA:567

 

CGMD11-Chronic Myelogenous Leukemia

Genes

BCR-ABL (translocation) HSA:613 25
EVI1 (overexpression) HSA:2122
AML1 (translocation) HSA:861
p53(mutation) HSA:7157
RB1 (mutation) HSA:5925

 

Markers

BCR-ABL (translocation) HSA:613 25
WT1 HSA:7490

 

CGMD12-Chronic Myeloproliferative Disorders

Genes

JAK2 (mutation) HSA:3717

 

 

Markers

JAK2 (mutation) HSA:3717
PRV-1 HSA:57126
EPO HSA:2056

 

CGMD13- Colorectal

Genes

beta-Cateninbeta-Catenin (mutation

HSA:1499

K-ras (mutation)

HSA:3845

APC (germline mutation (FAP), somatic mutation)

HSA:10297

DCC (deletion)

HSA:1630

TGF-betaRII (mutation)

HSA:7048

APC (germline mutation (FAP), somatic mutation)

HSA:10297

Smad2 (mutation)

HSA:4087

Smad4 (deletion)

HSA:4089

BAX (mutation)

HSA:581

p53 (deletion)

HSA:7157

MLH1 (germline mutation (HNPCC), LOH, promoter hypermethylation)

HSA:4292

MSH2 (germline mutation (HNPCC), LOH, somatic mutation)

HSA:4436

MSH3 (somatic frameshift mutation)

HSA:4437

MSH6 (germline mutation (HNPCC), LOH, somatic frameshift mutation)

HSA:2956

 

Marker

Hemoglobin

HSA:3039

3040

3043

K-ras (mutation)

HSA:3845

p53 (mutation)

HSA:7157

APC (mutation)

HSA:10297

BAT-26 (mutation)

 

CGMD14- Endometrial Cancer

Genes

K-ras (mutational activation)

HSA:3845

beta-Catenin (mutation)

HSA:1499

ERBB2 (amplification)

HSA:2064

PTEN (mutation, deletions, methylation)

HSA:5728

p53 (mutation)

HSA:7157

MLH1 (mutation, methylation)

HSA:4292

 

Markers

ER

HSA:2099

2100

PR

HSA:5241

CEA

[HSA:1048

CA125

HSA:94025

 

CGMD15- Esophageal Cancer

Genes

EGFR (overexpression)

HSA:1956

p53 (mutation)

HSA:7157

RB1 (LOH)

HSA:5925

iNOS (increased expression)

HSA:4843

COX2 (overexpression)

HSA:5743

APC(amplification)

HSA:324

Cyclin D1 (LOH)

HSA:595

FAS (increased expression)

HSA:355

 

Marker

p53

HSA:7157

TGF-alpha

HSA:7039

 

CGMD16- Gallbladder Cancer

Genes

p53 (mutation) HSA:7157
K-ras (mutation) HSA:3845
APC (mutation) HSA:324

 

Markers

Cyclin D1

HSA:595

Ki67

HSA:4288

p27KIP1

HSA:1027

 

CGMD17- Gastric (Stomach)Cancer

Genes

K-ras (mutation) HSA:3845
c-met (amplification) HSA:4233
K-sam (amplification) HSA:2263
ERBB2 (overexpression) HSA:2064
EGFR(overexpression) HSA:1956
EGF (overexpression) HSA:1950
TGF-alpha(overexpression) HSA:7039
VEGF (overexpression HSA:7422 7423 7424 2277
p53 (mutation, LOH) HSA:7157
APC (mutation, LOH) HSA:324
DCC (LOH) HSA:1630
E-Cadherin (mutation) HSA:999
beta-Catenin (mutation) HSA:1499
CD44 (abnormal splice variants HSA:960
Bcl-2 (LOH HSA:596
Cyclin E (amplification HSA:898 9134

 

Markers

CEA HSA:1048
CA19-9
CA-5
CA72-4

 

CGMD18- Hairy Cell Leukemia

Genes

p53 (mutation) HSA:7157
Bcl-6 (mutation) HSA:604
Cyclin D1(overexpression) HSA:595

 

Markers

CD103 HSA:3682
CD11c HSA:3687
CD2 HSA:3559
Annexin A1 HSA:301

 

CGMD19- Hepatocellular (Liver) Cancer, Adult Primary

Genes

PTEN (mutation) HSA:5728
H-ras (mutation) HSA:3265
K-ras (mutation) HSA:3845
N-ras (mutation) HSA:4893
AXIN1 (mutation) HSA:8312
beta-Catenin (mutation) HSA:1499
p53 (mutation) HSA:7157
p73 (mutation) HSA:7161
RB1 (mutation) HSA:5925
E-Cadherin (mutation) HSA:999
IGF2R (mutation) HSA:3482

 

Markers

AFP

HSA:174

AFP-L3 (LCA-bound fraction, the major glycoform of AFP)

DCP (PIVKA-II)

Glypican-3

HSA:2719

HS-GGT

HSA:2678

TGF-beta1

HSA:7040

 

CGMD20- Hodgkin Lymphoma, Adult

Genes

IKBA (mutation) HSA:4792
IKBE(mutation) HSA:4794
c-rel (amplification HSA:5966
CD95 (mutation)

 

Markers

CD30 HSA:943
IL-10 HSA:3586

 

CGMD21- Islet Cell Tumors, Pancreatic Neuroendocrine Tumors

Genes

MEN1 (mutation)

HSA:4221

 

Markers

MEN1 (mutation)

HSA:4221

p16/INK4A (deletion, methylation)

HSA:1029

 

CGMD22- Kaposi Sarcoma

Genes

Bcl-2(overexpression)

HSA:596
c-MYC (overexpression HSA:4609
c-INT(overexpression, mutation) HSA:2248
K-ras (overexpression, mutation) HSA:3845
p53 (mutation HSA:7157

 

Markers

 

CGMD23- Kidney (Renal Cell)

Genes

VHL (germline mutation (VHL disease), somatic mutation)

HSA:7428

Met (germline activating mutation (HPRC), somatic activating mutation)

HSA:4233

BHD (germline mutation (Birt-Hogg-Dube syndrome)

HSA:201163

PRCC-TFE3 (translocation)

HSA:5546

7030

 

Markers

CA9

HSA:768

p53

HSA:7157

Gelsolin

HSA:2934

Ki67

HSA:4288

CA12

HSA:771

Vimentin

HSA:7431

CD44

HSA:960

VEGF

HSA:7422

7423

7424

2277

 

CGMD24- Laryngeal Cancer

Genes

p53(mutation)

HSA:7157

Cyclin D1 (amplification)

HSA:595

EGFR (amplification)

HSA:1956

c-MYC (amplification)

HSA:4609

Cyclin E (amplification)

HSA:898

9134

 

Markers

p53 HSA:7157
Cyclin D1 HSA:595
EGFR HSA:1956

 

CGMD25- Lip and Oral Cavity Cancer

Genes

p53 (mutation, deletion)

HSA:7157

EGFR (overexpression)

HSA:1956

c-myc/N-myc (amplification, overexpression)

HSA:4609

N-ras (amplification, overexpression)

HSA:4893

K-ras (amplification, overexpression)

HSA:3845

Cyclin D1 (amplification, overexpression)

HSA:595

STAT-3 (expression)

HSA:6774

 

Markers

EGFR HSA:1956
Cyclin D1 HSA:595
Ki67 HSA:4288
AgNOR
RB1 HSA:5925
p53 HSA:7157
Zeta-chain

 

CGMD26- Lung Cancer Non-Small Cell

Genes

K-ras (mutation

HSA:3845

RAR-beta (promoter hypermethylation

HSA:5915

FHIT (mutation)

HSA:2272

RASSF1 (promoter hypermethylation)

HSA:11186

p53 (mutation/deletion)

HSA:7157

EML4-ALK (translocation

HSA:27436

238

TFG-ALK (translocation

HSA:10342

238

SLC34A2-ROS1(translocation

HSA:10568

6098

 

Markers

CEA

HSA:1048

CYFRA21-1

HSA:3880

 

CGMD27- Lung Cancer Small Cell

Genes

c-MYC (amplification)

HSA:4609

RAR-beta (promoter hypermethylation

HSA:5915

FHIT (mutation)

HSA:2272

p53 (LOH, mutation)

HSA:7157

RB1 (LOH, mutation)

HSA:5925

PTEN (mutation, deletion)

HSA:5728

Bcl-2 (overexpression)

HSA:596

 

Markers

ProGRP

HSA:2922

NSE

HSA:2026

 

 

CGMD28- Malignant Mesothelioma

Genes

p53 (inactivation

HSA:7157

p15/CDKN2B(deletion)

HSA:1030

NF2 (mutation

HSA:4771

PDGF-A (overexpression)

HSA:5154

PDGF-B (overexpression)

HSA:5155

IGF-1 (expression)

HSA:3479

IGF-R1 (expression)

HSA:3480

 

Markers

Calretinin HSA:794
WT-1 HSA:7490
Cytokeratin 5 HSA:3852
Cytokeratin 6 HSA:3853 3854 286887

 

CGMD29- Melanoma

Genes

BRAF (mutation) HSA:673
NRAS (mutation) HSA:4893
CDK4(mutation) HSA:1019
MITF (amplification) HSA:4286
PTEN (deletion, germline mutation, somatic mutation, LOH) HSA:5728
p53 (loss/mutation) HSA:7157

 

Markers

Vimentin HSA:7431
S100 HSA:6271
HMB-45
Mart-1/Melan-A HSA:2315
Tyrosinase HSA:7299
TyrP1 HSA:7306
TyrP2 HSA:1638
MITF HSA:4286

 

CGMD30- Nasopharyngeal Cancer

Genes

RASSF1 (promoter hypermethylation) HSA:11186
Bcl-2 (overexpression) HSA:596
EDNRB (promoter hypermethylation) HSA:1910
TSLC1 (promoter hypermethylation) HSA:23705
E-cadherin (decreased expression HSA:999

 

Markers


EBV-DNA

 

CGMD31- Non-Hodgkin Lymphoma

Genes

MYC-IgH (translocation) HSA:4609
p53 (mutation) HSA:7157

 

Markers

 

CGMD32- Ovarian Tumor

Genes

BRCA1 (germline mutation / deletion) HSA:672
BRCA2 (germline mutation / deletion) HSA:675
MSH2 (germline mutation) HSA:4436
MLH1 (germline mutation) HSA:4292
ERBB2 (amplification / overexpression) HSA:2064
K-ras (mutation) HSA:3845
AKT2 (amplification) HSA:208
PIK3CA (amplification) HSA:5290
c-MYC (overexpression) HSA:4609
p53 (mutation / deletion, overexpression) HSA:7157

 

Markers

CA125

HSA:94025

CA72-4

M-SCF CSF ]

HSA:1435

LPA (1-acyl-2-lyso-sn-glycero-3-phosphate)

OVX1

 

CGMD33- Pancreatic Cancer

Genes

K-ras (mutation) HSA:3845
ERBB2 (overexpression) HSA:2064
p53 (mutation) HSA:7157
SMAD4 (mutation) HSA:4089
BRCA2 (germline mutation) HSA:675
STK11 (germline mutation) HSA:6794

 

Markers

MIC-1

HSA:9518

CA19-9

Osteopontin

HSA:6696

K-ras (mutation)

HSA:3845

p53 (mutation)

HSA:7157

 

CGMD34- Penile Cancer

Genes

BMI1 (overexpression)

HSA:648

p53 (mutation)

HSA:7157

MDM2 (overexpression)

HSA:4193

H-ras (mutation)

HSA:3265

c-MYC (mutation)

HSA:4609

E-Cadherin (expression)

HSA:999

MMP-2 (expression)

HSA:4313

MMP-9 (expression)

HSA:4318

COX-2 (expression)

HSA:5743

PTGES2 (expression)

HSA:80142

 

Markers

Human papillomavirus types 16, 18

VGNM:NC_001526 NC_001357

Ki-67

HSA:4288

p53

HSA:7157

E-Cadherin

HSA:999

 

CGMD35- Prostate Cancer

Genes

AR (amplification, mutation)

HSA:367

CDKN1B (allelic loss)

HSA:1027

NKX3.1 (allelic loss) (decreased expression)

HSA:4824

PTEN (allelic loss

HSA:5728

GSTP1 (hypermethylation)

HSA:2950

TMPRSS2-ERG (translocation)

HSA:7113

2078

TMPRSS2-ETV1 (translocation)

HSA:7113

2115

TMPRSS2-ETV4 (translocation)

HSA:7113

2118

TMPRSS2-ETV5 (translocaiton)

HSA:7113

2119

SLC45A3-ETV1 (translocation)

HSA:85414

2115

SLC45A3-ELK4 (translocation)

HSA:85414

2005

DDX5-ETV4 (translocaiton)

HSA:1655

:2118

Markers

PSA

HSA:354

GSTP1 (hypermethylation)

HSA:2950

AMACR

HSA:23600

Telomerase

HSA:7015

PCA3 (prostate-specific non-coding RNA)

TB-15 (thymosin beta15)


 

CGMD36- Sarcoma, Soft Tissue

Genes

PAX3-FOXO1A (translocation) HSA:5077 2308
PAX7-FOXO1A (translocation) HSA:5081 2308
MDM2 (amplification) HSA:4193
ATR (amplification) HSA:545

 

 

Markers

PAX3-FOXO1A (translocation) HSA:5077 HSA:2308
PAX7-FOXO1A (translocation) HSA:5081 HSA:2308
MyoD1 HSA:4654
Myogenin HSA:4656

 

CGMD37- Skin Cancer, Nonmelanoma

Genes

p53 (mutation) HSA:7157
H-ras (mutation) HSA:3265
K-ras (mutation) HSA:3845

 

Markers

p63 HSA:8626